Objective To study the application value of kangaroo mother care combined with external application of rhubarb mirabilite to prevent postpartum milk stasis. Methods A total of 267 primiparas were enrolled， and randomly divided into routine group of 133 cases and combined group of 134 cases. The control group received routine postpartum nursing, and the combination group received kangaroo nursing combined with external application of rhubarb mirabilite on the basis of the routine group. The time of first breastfeeding, milk secretion patency, comfort, incidence of milk stasis, and neonatal feeding status and satisfaction were evaluated in the two groups of puerperal. Results The time of first breastfeeding in the combined group was significantly better than that in the conventional group. The combination group can effectively prevent the incidence of breast congestive swelling, milk stasis, and acute mastitis, thereby reducing the occurrence of breastfeeding interruption events caused by milk stasis and other reasons (P＜0.05). At the same time, the rate of exclusive breastfeeding for newborns in the combined group was significantly higher than that in the conventional group, and the maternal satisfaction evaluation was also significantly higher than that in the conventional group, and the difference was statistically significant(P＜0.05). Conclusion Kangaroo mother care combined with external application of rhubarb and thenardite can prevent postpartum milk stasis, and can significantly improve lactation, relieve breast discomfort, reduce complications, and improve breastfeeding rate. Kangaroo mother care combined with external application of rhubarb mirabilite is worthy of clinical application.