Diabetes belongs to the category of "diabetes of thirst" in traditional Chinese medicine and is a relatively common chronic disease. This case reports the diagnosis and treatment of a critically ill patient with type 2 diabetes. The patient clinically experienced difficulty in urination, incomprehensible defecation, coma, and the wound, did not heal for a long time. Professor Zhang Xiaolin believed that long-term illness yin damage and yang, yin and yang are all deficient, and it is not good to engrave the cardinal of Shaoyang Sanjiao, so she gave Xiaochaihu Decoction to reconcile Shaoyang and Tongli Sanjiao, Shengmaiyin and American ginseng to strengthen Qi and detox, and use Jinkui Shen in combination. Qi Pill?蒺s yin and yang supplementation, combined with the supportive treatment of western medicine, has a significant clinical effect, which provides a new idea for clinical practice.