To explore the application of rain classroom combined with BOPPPS teaching model in science of Chinese materia medica and evaluate the teaching effectiveness of this teaching model, rain classroom was organically combined with the BOPPPS model to construct RC-BOPPRS teaching mode by changing the post-assessment of BOPPPS model to a real-time assessment according to the convenient in-class test of rain classroom, and the usefulness of this teaching model was assessed in science of Chinese material medica courses for undergraduate students from Chinese medicine major at Yunnan University of Chinese Medicine. Results show that RC-BOPPRS teaching mode can improve student academic performance in science of Chinese material medica courses, and the surveyed students hold that this teaching mode is helpful for defining learning objectives, enhancing learning interesting, developing autonomous learning ability, promoting interaction and communication between teacher and student. Collectively, RC-BOPPRS teaching mode is superior to traditional teaching mode, and also could provide a reference for teaching reforms of other related courses.