Objective To study the mechanism of improving Alzheimer‘s disease(AD) by using network pharmacology and molecular docking methods. Methods TCMSP database was used to screen the active components and corresponding targets of Notoginseng Flos, DisGeNET database and GeneCards database to find relevant targets of AD, and Cytoscape 8.0 software to construct "active component-target" association network, and perform GO function enrichment and KEGG pathway analysis of key targets. The selected active components and targets of Notoginseng Flos were verified by molecular docking. Results 23 components of the active components of Notoginseng Flos Correlated to 34 AD targets. Among them, sitogluside, β-sitosterol and β-copolyside might improve AD by regulating CHRM 1, CHRM 2 and PTGS 2, β-sitosterol(beta-sitosterol), especially west polysoside, β-sitosterol and PTGS 2 and CHRM 2. And sitogluside, β-sitosterol were strongly bound with the targets. Conclusion The active components of Notoginseng Flos may intervene in AD by regulating CHRM 1, CHRM 2, PTGS 2, ADRB 2, SLC6A4, PTGS 1, RELA, IL 10, and PI3K-Akt signaling pathway.