Objective To observe the effect of catgut embedding at "Neiguan PC6" and "Xinshu BL15" acupoints on Mer receptor tyrosine kinase (MerTK) related expression of macrophages in rats with myocardial infarction, and to explore the possible mechanism of catgut embedding at "Neiguan PC6" and "Xinshu BL15" acupoints on myocardial hypertrophy. Methods Male rats (SD) were randomly divided into sham, model, "Neiguan PC6" and "Xinshu BL15" acupoint catgut embed, perindopril and 5 rats in each group. Intervention treatment started on the second day after operation, with 7 and 28 days as observation points. Hematoxylin eosin(HE) staining was used to observe the pathological morphology of myocardial tissue, and enzyme-linked immunosorbent assay(ELISA) was used to detect serum IL-6, TNF-α, IL-1β The expression of MerTK and p-Mertk protein in myocardium was detected by Western blotting. Results (1) Compared with the rats in the sham operation group, 7 and 28 days after the model was constructed, the myocardial cells in the model group were abnormal in morphology and disordered arrangement, and the number of free nuclei was increased. There was obvious intercellular substance and the cross-sectional area of myocardial cells was increased(P<0.05). Serum IL-6, TNF-α，IL-1β The concentration showed a significant upward trend, MerTK protein expression decreased (P<0.05), p-MerTK protein expression increased (P<0.05). (2) Compared with rats in the model group, on the 7th and 28th day after treatment, the shape and size of myocardial cells stained with HE in the two treatment groups were relatively regular, and the arrangement was relatively parallel and orderly. The situation of myocardial cell nuclear dissociation and hypertrophy was improved to varying degrees, and the cross-sectional area of myocardial cells was reduced to varying degrees(P<0.05). IL-6, TNF-α， IL-1β The concentration decreased(P<0.05), MerTK protein expression increased in varying degrees(P<0.05), and p-MerTK protein expression decreased in varying degrees. Conclusion "Neiguan PC6" and "Xinshu BL15" catgut embedding can improve the degree of myocardial hypertrophy in rats with myocardial infarction. The mechanism may be related to maintaining the expression of macrophage surface receptor MerTK in myocardial tissue and reducing the content of serum inflammatory cytokines.