Luteoride A is a potentially bioactive indole alkaloid, which has attracted much attention due to its presence at site 3 and site 7 of (E) oxime group and trans isoprene group, which are not common in natural products, respectively. A simple and efficient method for the synthesis of Luteoride A with only one key reaction step and a total yield of 78% was proposed by using atomic economy, high regional selectivity and stereoselectivity (e-isomer) formal alkylation reaction and novel Heck-dehydration reaction.