[Objective]It is pointed out that "Treatise on Febrile Diseases" attaches great importance to the interpretation of pathogenesis, in which the research on the pathogenesis of treatment response based on the response of treatment is beneficial to clinical application.[Method]Through objective and comprehensive analysis of the original text of "Treatise on Febrile Diseases", including pathogenesis analysis based on drug effect response after drug treatment, pathogenesis analysis based on drug efficacy response of drug probing, pathogenesis analysis based on response to fire therapy or acupuncture treatment, and basis The pathogenesis of treatment response after mistreatment is analyzed, and the pathogenesis theory of treatment response in "Treatise on Febrile Diseases" is explained in detail.[Results]"Treatise on Febrile Diseases" attaches great importance to the explanation of pathogenesis. Zhongjing"s methods of understanding pathogenesis are also diverse, among which the pathogenesis of treatment response is quite original and worthy of in-depth study.[Conclusion]A detailed explanation of the pathogenesis theory of treatment response in "Treatise on Febrile Diseases" has important enlightening significance and guiding value for the research and application of pathogenesis theory of "Treatise on Febrile Diseases" and TCM syndrome differentiation theory, as well as the improvement of clinical efficacy. Keywords: Treatise on Febrile Diseases; treatment response; pharmacodynamic response; pathogenesis