The Bi syndrome is a disease name in traditional Chinese medicine, characterized by pain, soreness, numbness in the limbs bones, joints, muscles and other parts. It may also be accompanied by joint flexion and extension limitation and swelling. In modern medical system, diseases related to joint pain such as rheumatoid arthritis, gouty arthritis, osteoarthritis are classified as Bi syndrome. Although the treatment of Bi syndrome is not directly discussed in Treatise on Febrile Diseases, there are already statements related to Bi syndrome and classic prescriptions contained in it which have achieved remarkable results in clinical treatment of Bi syndrome. With the deepening study of the prescription of Treatise on Febrile Diseases, modern scientific research has gradually revealed the internal mechanism of these prescriptions for treating Bi syndrome. This paper discusses the statements and prescriptions related to Bi syndrome in Treatise on Febrile Diseases to provide useful enlightenment and methods for clinical application of traditional Chinese medicine for treating Bi syndrome.