Objective This study aims to optimize the processing technology and parameters for fresh slices of Angelica sinensis Diels by combining medicinal component content detection with orthogonal testing. Methods The effects of impurity treatment methods, thickness, and drying methods on the appearance, internal structure, and content of medicinal components(ferulic acid and volatile oil) in fresh slices of Angelica sinensis Diels were investigated. The processing technology for fresh slices of Angelica sinensis Diels was then optimized using an L9(34) orthogonal test, with the ferulic acid content as the index. Results The optimized processing technology and parameters for fresh slices of Angelica sinensis Diels were determined as follows: First, the reed head, the fibrous roots, soil and impurities were removed or washed from the surface of the plant. The sample was then dried until there was no water dripping from the surface. Next, the plant was dried in a greenhouse until the cloud Angelica must and the tail(diameter within 4 mm) became dry, and the body became soft. The whole plant was then cut into 4mm thick slices and further dried in the greenhouse, and the yun angelica Yinpian are obtained. The ferulic acid and volatile oil contents were 0.2211% and 0.9% respectively. The quality of Radix Angelicae sinensis slices processed using this optimized technology is superior to that of slices obtained by traditional methods(the acid and volatile oil contents were 0.1930% and 0.8%). Conclusion The optimized processing technology is reasonable and feasible, laying a solid foundation for the pharmaceutical processing of fresh slices of Angelica sinensis Radix.