针刺联合耳穴治疗围绝经期失眠症状临床疗效的Meta分析
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1.云南中医药大学;2.云南中医药大学第二临床医学院

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云南省卫健委“2020年高层次中医药人才培养对象”资助项目(云卫中医发展发〔2021〕1号)


Meta-analysis of clinical efficacy of acupuncture combined with auricular points in the treatment of perimenopausal insomnia symptoms
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Yunnan University of Traditional Chinese Medicine Second Clinical School

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    摘要:

    目的: 评价针刺联合耳穴治疗围绝经期失眠患者睡眠质量的有效性。方法: 本研究采用计算机检索技术,对CNKI、万方数据平台、维普期刊全文库以及中华医学会期刊数据库、Pubmed等数据库进行了全面检索。检索关于针刺联合耳穴治疗围绝经期失眠患者的临床随机对照(RCT)试验,由2名文献检索员独立进行文献的筛选、资料提取、文献质量评价、偏倚风险评价,最后对符合要求的RCT使用RevMan5.4软件进行Meta分析。结果:最终共纳入文献11篇,共1038例围绝经期失眠患者。Meta分析结果显示:相对于对照组,针刺联合耳穴组匹兹堡睡眠质量指数(PSQI)评分[MD=-4.06,95% CI(-5.25~-2.87),P<0.001)、促卵泡激素(FSH)(MD=-5.86,95%CI(-10.37~-1.35),P=0.01)、Kupperman评分(MD=-2.65,95%CI(-2.91~-2.39),P<0.00001)、MENQOL(MD=-7.16,95%CI(-8.22~-6.09),P<0.00001)、总有效率(MD=4.26,95%CI(2.77~6.55),P<0.00001)均有效改善;而血清E2水平(MD=-10.95,95%CI(-58.57~36.67),P=0.65)、LH水平(MD=-4.18,95%CI(-9.67~-1.31),P=0.14)与对照组效果相当。结论: 采用针刺联合耳穴疗法能有效提升围绝经期失眠患者的睡眠质量,其疗效相较于中成药、西药治疗、单纯针刺或单纯耳穴治疗展现出显著优势。但对血清E2、LH水平影响不明显,是中医治疗围绝经期失眠症状的有效方法。但因受文献数量及质量的限制,最终分析结果的科学性和可靠性还待商榷,其机制仍有待深入探讨。

    Abstract:

    To evaluate the effectiveness of acupuncture combined with auricular points in the treatment of sleep quality in patients with perimenopausal insomnia. Methods : In this study, computer retrieval technology was used to conduct a comprehensive search of CNKI, Wanfang data platform, VIP journal full library, Chinese Medical Association journal database, Pubmed and other databases. A randomized controlled trial ( RCT ) of acupuncture combined with auricular points in the treatment of perimenopausal insomnia was retrieved. Two literature searchers independently screened the literature, extracted the data, evaluated the quality of the literature, and evaluated the risk of bias. Finally, Meta-analysis was performed using RevMan5.4 software for RCTs that met the requirements. Results : A total of 11 literatures were finally included, with a total of 1038 patients with perimenopausal insomnia.The results of Meta-analysis showed that : compared with the control group. The Pittsburgh Sleep Quality Index ( PSQI ) score [ MD =?4.06,95 % CI (?5.25 ~ ?2.87 ), P<0.001 ], follicle-stimulating hormone (FSH) ( MD = ?5.86,95 % CI (?10.37~ ?1.35 ), P =0.01), Kupperman score (MD =?2.65,95 % CI (?2.91~ ?2.39 ), P <0.00001), MENQOL ( MD =?7.16,95 % CI(?8.22~?6.09), P < 0.00001 ), total effective rate (MD=4.26,95 % CI (2.77 ~ 6.55), P < 0.00001) were effectively improved in the acupuncture combined with auricular point group. The serum E2 level ( MD = ?10.95,95 % CI (?58.57 ~ 36.67 ), P = 0.65 ) and LH level ( MD = ? 4.18,95 % CI (?9.67 ~ ?1.31 ), P = 0.14 ) were comparable to the control group.Conclusion : Acupuncture combined with auricular point therapy can effectively improve the sleep quality of patients with perimenopausal insomnia, and its curative effect shows significant advantages compared with Chinese patent medicine, western medicine treatment, simple acupuncture or simple auricular point therapy. However, it has no obvious effect on serum E2 and LH levels, which is an effective method for traditional Chinese medicine to treat perimenopausal insomnia. However, due to the limitation of the quantity and quality of the literature, the scientificity and reliability of the final analysis results are still to be discussed, and the mechanism remains to be further explored.

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  • 收稿日期:2024-10-20
  • 最后修改日期:2024-11-06
  • 录用日期:2024-11-07
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