Objective:to investigate the clinical effect of Quban-Meifu decoction(QMD) on chloasma patients.Methods:128 chloasma female patients were divided into two groups at random.One group with 74 patients was treated with QMD daily,the control group with 54 patients was treated with Xiaoyao pill and Vitamin C and E.Treatment was continued for 30 datys.Results:Total effective rate in the treatment group was 8649%,and that of control group was 5926%,and the difference was significant(P＜005).