Objective: To explore the effect of Xiaoyitang and danazol on the expression of VEGF and MVD in ectopic endometrial tissue in female rats with endometriosis. Methods: Wistar rats endometriosis models were established ,successful endometriosis rats were divided into control group, XiaoYiTang group, danazol group, minimal combination group, medium combination group,large combination group. Ectopic endometrium grafts volume and histomorphology were observed, vescular endothelial growth factor(VEGF) was observed in ectopic endometrium by immunohistochemistry(SABC technique). MVD was determined by immunostaining for CD31.Results:It was confirmed with pathology that the rat model was made successfully by autotransplantation of its own endometrium between the superficial and muscular layer of the abdomial wall. Ectopic endometrium grafts volume has no significant difference in six group before treatment（P＞005）. there was diminished significantly after treatment ( P＜005) ,which effects are dose-dependent. MVD and the level of VEGF in the ectopic endometrium was decreased significantly after treatment, which effects are dose-dependent. And ectopic endometrium grafts volume, or MVD, or the level of VEGF has no significant difference between danazol group and minimal combination group after treatment. Conclusion: XiaoYiTang can decrease the quantity the microvessel and the expression of protein VEGF in heterotopic endometrium of endometriosis rats. XiaoYiTang not only can improve the curative effect of danazol but also can reduce the dose of danazol when combining with danazol.