Objective:To prepare and research Palmatine pellets.Methods:According to the orthogonal experimental design,and selected the best palmatine pellets preparation,and optimize the coating process pellets,and enhance the stability of preparations.Results:The optimum conditions were screened out as A3B3C3,which was distilled water(215g/1 000 tablets),spheronization machine frequency(32Hz)and microcrystalline cellulose(33%),Palmatine pellets were successfully prepared;The optimized coating conditions were established as follows;ILE coating powder,coating concentration(14%),coating weight(4%),Palmatine pellets were coated,Palmatine pellets enhanced the anti-wet.Conclusion:The process was scientific and rational.