Objective:To investigate the effects on coronary heart disease(CHD)for the syndrome element change of the nature of disease from“the Phlegm”to“the Phlegm and Blood Stasis”.Methods:To detect the blood-fat,blood rheology,blood glucose, insulin sensitivity index(ISI)and the expression of related genes from 120 CHD patients with syndrome of blockage of phlegm and blood stasis(Group 1),98 CHD patients with syndrome of stagnation of phlegm in blood vessel(Group 2),92 CHD patients with syndrome of non phlegm and non blood stasis(Group 3)and 30 healthy persons for control group(Controlgroup).Results:Group 2 have significant differences compared with Group 3 and Control group（P＜001）.All indexs of blood rheology have gradual increase from Group 3,Group 2 to Group 1.Similarly,FINS(Fasting blood insulin)and ISI both have a increased tendency from Control group,Group 3,Group 2 to Group 1 too(P＜001).In the process of pathologic evolution,from Group 3, Group 2 to Group 1, the expression amount of c-myc mRNA and PDGF-A mRNA have progressive increase.Conclusion:First,the abnormality of blood rheology is the objective index of stagnation of blood vessel.Second,IR is the important inner biochemistry basic,which produces“the Phlegm and Blood Stasis”,also develops“the Phlegm”to“the Blood Stasis”.Third,there is a positive correlation between IR and pathological changesdegree of coronary artery,which indicates that IR can be used as a indication to predict CHD.Last,the changes of the Phlegm and Blood Stasis syndrome element of CHD relates to abnormal expression of c-myc,PDGF-A mRNA.