Objective:Observe the TCM therapy of“cure the spleen”curative effects of diabetic nephropathy in earlier and intermediate stage.Methods:There are 88 patients who suffer from Type 2 diabetes nephritics in Ⅲ-Ⅳ period and hypertension.The 88 patients are divided randomly into treat group and control group,the treat group have 45 subjects, and control group have 43 subjects.Tow groups are equally afforded by diabetesroutine treatment.Meanwhile, treat group is based on it and add to the traditional Chinese medicine treat for one month. Results:①The genera effective rate in the treat group is better to control group（P＜005）②The treat group has a good effect on abate the symptoms as thirsty,drinks,upset,and insomnia.Compared with control group,the total effective rate of treat group are better（P＜005）;But more feed and more urinary symptoms improved comparative differences were not significant between tow groups（P＞005）.③The UAER declined after treatment than before in treat group（P＜001）,and The UAER declined after treatment than before in control group（P＜005）;After treatment,the UAER in treat group dropped more obvious than control group（P＜005）.Conclusion:Traditional Chinese medical therapy though“cure the spleen”improved the symptoms and UAER of diabetic nephropathy in earlier and intermediate stage obtained better curative effects than routine Western medicine treatment.There is a good clinical value of Traditional Chinese medicine in treating diabetic nephropathy though“cure the spleen”.