To explore the relevance between the familial inherited characteristics of Diabetes Mellitus and Blood stasis syndrome. Methods: We divided 2269 T2DM patients into 2 groups: positive T2DM family history group and negative T2DM family history group. According to the Blood stasis syndrome questionnaire involving 18 items of TCM symptoms, the total scores of Blood stasis syndrome were obtained. And then the data of 2269 patients were compared to analyze the difference between the patients with positive T2DM family history and negative T2DM family history. Results: There were 444 cases with positive T2DM family history, which accounted for 1925% of all investigated. Patients with Blood stasis syndrome accounted for 2953% of total investigated. There were 156 cases in positive T2DM family history group and 514 cases in negative T2DM family history group. The total scores of Blood stasis syndrome questionnaire, obtained by patients with positive T2DM family history, were significantly higher than those obtained by patients with negative family history (P value<001). Conclusion: Distribution of Blood stasis syndrome in T2DM pedigrees showed a familial aggregation trend and the degree of Blood stasis syndrome showed a direct correlation with the T2DM family history.