Objective：We used the methods in CHP to analog the stomach and intestine environment to study the stability of scutellarin in simulated gastric fluid and simulated intestinal fluid.Methods:Put scutellarin into artificial stomach and intestines of the artificial,With HPLC and LC-MS results.Results:Scutellarin appearing degradation products which has been identified to be scutellarein in 05h~25h.But in simulated intestinal liquid dont have an object becomes degradation.Conclusions:Scutellarin was not stable in simulated gastric liquid，but it was stable in simulated intestinal liquid.