Objective:Optimization of double Jiedu oral liquid by ultrasonic extraction technology of honeysuckle.Methods:Using L9 (34 ) orthogonal table is preferably ethanol extraction process conditions,with the effective components of honeysuckle Lv Yuan acid as the evaluation index,the HPLC method for the determination of Lv Yuan acid content;Results:After validation test to determine the optimum craft:65% ethanol soaking herbs 05h,each 1H extraction,extracting for 3 times;Conclusion:Optimization of double Jiedu oral liquid honeysuckle ultrasonic extraction process is stable and reasonable and feasible.