Objective:to study with chronic nephritis,diabetic nephropathy,impotence disease were studied in typical kidney Yang syndrome transcription group learning characteristics,this paper reveals the kidney Yang syndrome“treating same pattern with different method”the biological basis. Methods:to 9 cases were different disease of kidney Yang syndrome,Agilent people 444k expression profile chip experiments,the difference between the gene expression Pathway analysis.Results:find out three different disease kidney Yang syndrome of common article 332 differentially expressed genes,including the comment for article 181 genes.Three different disease kidney Yang syndrome common signal pathway is 37.And from the three groups of disease their unique differentially expressed genes found in mTOR,notch,Wnt as 3 signal path and kidney Yang syndrome were signal path consistent,just in the path of the regulation on the gene expression differences.Conclusion:three diseases of the special differentially expressed genes related to signal transduction article three of the differences may decide the kidney Yang syndrome“treating same pattern with different method” the basic of transcriptomics.