Objective: To select the optimum preparation technology for granules of Bupleurum and Agastache. Methods: The optimum preparation technology examined by L9(34) refer to the synthetic process that proportion of powder and auxiliary materials,proporation of powdered sugar and dextrin, and adhesive used as detected factors and the mobility as detected index, which aim to find the best preparation of parameters. Result: The proportion of powder and auxiliary materials was 1∶15, proportion of dextrin and powdered sugar was 1∶5,and optimum preparation technology of experiment, which were the best conditions of optimum preparation technology found in this experiment. Conclusion: This preparation technology made in this research was convenient, steady and controllable, which provided pilot process with scientific basis.