Objective: To study the therapeutic effects of polysaccharides from Bletilla Striata (BSP) on gastric ulcer rats. Methods: The models of gastric ulcer were established by pylorus-ligation, acitic-acid-firing and alcohol-damage. Experimental SD rats were randomly divided in 6 groups. Each group rats started to be administrated as fellows. Positive control group received 01g/kg Cimetidine (ig). High, middle and low dose BSP groups received 80, 40 and 20mg/kg BSP (ig). Sham operation group and negative model group received isovolumic normal sodium (ig). According to Guth-criterion, the ulcer index was determined and the inhibition ratio were calculated. Results: Compared with the model group, BSP inhibited gastric ulcer significantly，and promoted healing of gastric ulcer.