Objective:The research is trying to observe the influence of Turbidity-reducing Granule on α- SMA of Rats with five sixes kidneys cut with chronic renal failure so as to observe the mechanism of the granule in its therapy function for CRF and its resistance mechanism of renal interstitial fibrosis. Methods: 5/6 subtotal nephrectomy method (two surgeries) to establish CFR rats. Rats were Fed administered or saline 60 consecutive days.Immunohistochemical staining (SP method) were used to detect α-SMA expression.Results: Turbidity-reducing Granule can reduce the experimental rat kidney tissue α-SMA expression， and had significant difference with model control group (P＜005), There was no significance between Turbidity-reducing Granule group and benazepril control group (P＞005).Conclusion: It is concluded that Turbidity-reducing Granule can prevent the express of rat kidney’s α-smooth muscle antibody; In addition it can interfere with the interstitial fibrosis of kidney and prolong the progress of rat’s CRF.For this,,and its effect can match that of Benazepril.