Objective: By comparing the changes of VEGF in endometriosis model rats’ectopic endometrium in before and after using BenShiHuPoSan(BSHPS),we discuss about the effects of BSHPS on angiogenesis in Endometriosis. Methods: First, establish the rat model of EMs by transplanting autologous endometrium to the abdominal wall. Then divide the rats randomly into 5 groups: normal group, pseudo operation group, disease group, BSHPS group and danazol group. Finally, detect the contents of VEGF in endometrium by Western Blot, after dosing for 4 weeks. Results: Compared with the normal group, the content of VEGF in ectopic endometrium of disease group is much higher. Compared with disease group, the content of VEGF in ectopic endometrium of BSHPS group is significantly reduced (P＜005). Conclusion: BSHPS can reduces the content of VEGF in EMs model rats’ectopic endometrium, and inhibites angiogenesis to treat EMs.