Objective: To observe the effects of the cultivation of purple, white and yellow color types of Lepidium meyenii (Maca) cultivation in Yunnan on nonspedific immunity, fatigue resistance and hypoxia tolerance function, meanwhile, to provide the experimental basis for the development of health food and the further research of the active material. Methods: The mouse models of cyclophosphamide induced immunosuppression, weight loading swimming and normobaric hypoxia were made. The mononuclear macrophage phagochtosis ability, weight loading swimming time and hypoxia tolerance time were chose as the evaluation index. Results: The mononuclear phagocytic capacity of immunity deficiency mice was improved by three kinds of Maca (P<0.01); Three color types of Maca could significant extend the weight loading swimming time of mice(P<001 or P<0001), especially the purple Maca, then the yellow Maca. The hypoxia tolerance time were extended by the purple and yellow Maca (P<0001), especially the purple Maca. Conclusion: The three color types of Maca cultivated in Yunnan had the similar efficacy with which cultivated in Peru as reported. the efficacy of purple Maca was the most significant, then the yellow one, and then the white one.