Objective: To approach the influence factors on TCM syndrome differentiation-typing such as age of disease onset, duration, family history, body mass index, associated symptoms, medication history and living habits in patients with symptoms of type 2 diabetes. Method: The data from 545 inpatient cases of type 2 diabetes in department of endocrinology，The First Affiliated Hospital of Yunnan University of TCM，were investigated by epidemiological method, and all the patients were interviewed in this study.Results: It showed that the age of disease onset and duration significantly correlated to TCM differentiation-typing respectively. Further more, the incidence of excessive heat damaging fluid syndrome in old patients was less than that in non-old patients. In contrast, the rate of Qi and Yin deficiency with blood-stasis syndrome were gradually raised with the increasing of age. The rate of excessive heat damaging fluid syndrome, liver and kidney Yin deficiency and Qi and Yin deficiency of lung decreased proportionally with longer duration of diabetes, but the rate of liver and kidney Yin deficiency with blood-stasis syndrome, Qi and Yin deficiency with blood-stasis syndrome and deficiency of both yin and yang syndrome increased（P＜001 significant）. Studies showed that body mass index were no correlation with TCM syndrome differentiation-typing（P＞005）.Compared with other syndrome-type groups, the percentage of excessive heat damaging fluid syndrome in patients complicated by ketosis-prone was much higher（P＜005 significant）.There was significant increasing both in liver and kidney deficiency with blood stasis syndrome and Qi and Yin deficiency with blood-stasis syndrome groups in patients complicated by diabetic oculopathy, diabetic nephropathy and diabetic peripheral neuropathy（P＜001 significant）.Other factors such as high blood pressure,lipid metabolism disorders,cerebral vascular disease and other complications （hyperuricemia,gout and coronary heart disease） weren’t show significant correlation with TCM differentiation-typing of diabetes（P＞005）.