Objective:The hypothalamic-pituitary-adrenal(HPA)axis suppression and septic shock model was duplicated and the effects of Sini Decoction was evaluated on that.Methods:We evaluated the effects of Sini Decoction on HPA axis suppression model by determining the levels of serum corticosterone（ CORT）and ACTH, calculating the index of adrenal gland and observing the pathologic changes of bilateral adrenal gland. Blood pressure measurement was made before and after HPA axis suppression and septic shock model duplicated. Results:After subcutaneous injection of CORT (10mg/kg) for fourteen days,once a day, serum CORT of model group was lower compared with normal group(P<005). The large and small dose groups of Sini Decoction exhibited higher CORT than model group(P<005， P<001). ACTH and the weight of adrenal gland increased in high dose group of Sini Decoction(P<005).Pathologic examiniation showed, the shrinking of adrenal bilateral adrenal gland,sizes decreasing of zona glomerulosa and zona fasciculata cell and the increasing vacuoles in cell fat were improved in the low and high doses of Sini Decoction groups.In infectious shock model rats induced by LPS, blood pressure was decreased,however,it could be controlled in positive group（5mg/kgDEX）, prophylactic and treatment groups of Sini Decoction（P<001）.Conclusion：Administration of Sini Decoction improved the suppression of HPA axis, relieved the bilateral adrenal gland atrophy due to exogenous GC and elevated the blood pressure of HPA axis suppression and septic shock model rats.