Prescription of traditional Chinese medicine（TCM）is an important part of principle-method-recipe-medicines. Becuse of the different effects of each medicine material，their curative effects depend on how to combine them together reasonably，so it is essential for TCM-clinic to pay attention to the compatibility of Chinese medicine materials. Under the guidance of “Variable-Stable and Sequential Eight Methods”theory，this article rethinked the present compatibility form and their deficiencies，expounded the distinguishing feature of this theory about how to combine Chinese medicine materials together felicitously：depend on core pathogenesis，use a string of Chinese medicine materials as an unit which fixed relatively and changing dynamicly. And suggested that we should break the fixed thinking mode，probe a more perfect principle about compatibility of Chinese medicine materials on the basis of summing up practice experience constantly，make it to be a better guidance of clinical activity.