Objective：To explore the compound notogin sengnano drug to head injury rat serum tumor necrosis factor-α, interleukin -2 and interleukin -6, the effects of the compound notogin sengnano drug validation of head injury after the body of protection. Methods:96 mouse randomly divided into the sham group, the trauma model group, notogin sengnano drug group and nimodipine groups, namely to physiological saline、physiological saline、notogin sengnano drug、nimodipine irrigation stomach 5d, made in the 1, 3, 5d abdominal aortic blood samples taken puncture enrol your biometrics, observing four groups serum tumor necrosis factor-α, interleukin-2 and interleukin-6 content. Each group of each phase to choose only 8 random complete detection. Results:Four group serum tumor necrosis factor-α，interleukin -2 and interleukin and comparison, the effect and time intervention main effects are statistically significant difference (P<0.05). Conclusion:Notogin sengnano drug can reduce head injury in serum rat tumor necrosis factor-α, interleukin -6 content and increase interleukin-2 expression.