Objective: To observe the pluse characteristic of HIV/AIDS patients receiving 52weeks HAART, and its relationship with CD+4T Cell . Methods: 80 HIV/AIDS patients whose CD+4T≤300 cell/ul were measured by ZM-Ⅲ PLUSE ANALYTICAL INSTRUMENT before the treatment and after 52weeks treatment respectively. Uses the wilcoxon rank sum test of SPSS110 software package to carry on the data analysis , the pulses of patients at different CD+4T levels are analyzed,while the differences between before and after treatment are compared also.Results:1. The pluses measured after 52weeks-treatment are more normal than that measured before the treatment. 2. The research on pulse characteristic before HAART shows that the pulse of the patients in lower CD+4T levels are more likely to exists as deficient pulse ， deep pluse ，or other Abnormal pluses. Conclusion：1.The pulses characteristic 0f low level CD+4T Cell patients is ZHENG XU XIE SHI.2. There exists some relation between pluse and CD+4T Cell,but the abnormal pluse also be found in patients of higher CD+4T Cell level .3. PLUSE ANALYTICAL INSTRUMENT can contribute to Traditional Chinese Medical research.