Objective To screen and verify differentially expressed genes from Cerebral Palsy with spleen and kidney deficiency syndrome. Methods 15 characteristic genes related with the disease and syndrome were chosen to be verified from the differentially expressed genes screened from earlier cDNA microarray of “normal-CP” twin with spleen and kidney deficiency syndrome. 11 Cerebral Palsy with spleen and kidney deficiency syndrome children were selected as experimental group， and 10 healthy children were selected as control group. The expression of screened differential genes was compared between two groups through RT-PCR test. Results The expressed level of FIGN and PTGER2 had the significant differences between experimental group and control group. FIGN was significantly low expressed， and PTGER2 was significantly high expressed in experimental group compared to that of the control group（P<0.01）. Conclusion There is correlation between the abnormal expression of FIGN and PTGER2 and Cerebral Palsy with spleen and kidney deficiency syndrome .It can be inferred that the two genes may be the candidate marker-gene of Cerebral Palsy with spleen and kidney deficiency syndrome.