Objective To study the clinical efficacy of “Bushen Huoxue Decoction” in treating primary osteoporosis. Methods To count and analyze efficacy of the two groups，the treatment group with 36 cases of primary osteoporosis was treated with Bushen Huoxue Decoction and western medicine，while the control group with 36 cases of primary osteoporosis was treated with western medicine alone. Results The clinical efficacy and the reduction of pain intensity in the treatment group were better than in the control group（P<0.05），the efficacy of TCM syndrome in the treatment group was obviously better than in the control group（P<0.01），the improvement of TCM syndrome score in the treatment group was better than in the control group（P<0.05）.The BMD of two groups were rising after treatment，but there was no statistically significant（P>0.05）. Conclusion The efficacy of” Bushen Huoxue Decoction”in treating primary osteoporosis is perfect，it is meaningful to do popularizing of clinical application.