Objective The anti-senility effects of Polygoni Multiflori Radix（PMR）and its processed products including traditional processed products on human embryo lung diploid fibroblast cells were investigated in order to find the best processing time of PMR. Methods The diploid cells were counted and the SOD activity. It were tested after exposed by extracts of PMR and its processed products with different processing time including traditional processed products. Results The resistance attenuation rate of 3 h processed PMR group was 38.04% and the SOD activity in 3 h processed PMR group was(71.85±5.04)U·mL-1. The SOD activity and the resistance attenuation rate of diploid cells in 3 h processed PMR group were significantly higher than the control group（P<0.001）. Conclusion 3 h processed PMR could delay the decline of human embryonic lung cells while increase SOD activity in HEL cells. Thus，the most apporatiate processing time of PMR was 3 hours high-pressure steaming.