Objective In order to observe the Fangji Huangqi Decoction and modified Fangji Huangqi Decoction on expression of P-cadherin and FSP-1 gene in TGF- β1-induced podocytes. Methods Unified cultured podocytes，then divided into 4 groups after the differentiation and maturation. Podocyte of model group and normal group were incubated in culture medium containing 10% normal rat serum，the model group and intervention group with TGF- β 1 stimulates，intervention group were respectively based on the medium containing 10% Fangji Huangqi decoction，10% modified Fangji HuangqiDecoction drug-containing serum of rats with. Using reverse transcription polymerase chain reaction(RT-PCR)technique for the detection of P-cadherin，FSP-1 gene expression. Results Compared with normal group，model group，P-cadherin gene expression was significantly reduced，while FSP-1 was no significant difference；Compared with the model group，the intervention group the expression of P-cadherin is significantly increased，the normal group，model group，and intervention group had no significant difference in FSP-1 expression. Conclusion Fangji Huangqi Decoction and modified Fangji Huangqi decoctioncan maintain podocyte phenotype molecule expression.