Objective To investigate the intervention effects on related risk factors with acupuncture in ischemic stroke patients. Methods 60 patients with ischemic stroke were randomly divided into acupuncture group and routine treatment group，30 in each group. The patients in acupuncture group were treated by acupuncture，while the patients in routine treatment group were treated by aspirin 75 mg/d. The course of treatment was one month，totally 3 courses. The blood lipid，cerebral blood flow，hemorheology，blood pressure，blood glucose，SOD and MDA were detected before and after the treatment cycle. Results The changes of blood lipid，cerebral blood flow，hemorheology，blood pressure，blood glucose，SOD and MDA have significantly different before and after the treatment cycle in acupuncture group（P<0. 05 or P<0. 01）. And the levels of TG、HDL-C、Vmin、PI of LMCA and Vmax，Vmin，RI of RMCA，whole blood viscosity，plasma viscosity，hematocrit，fasting blood glucose，systolic pressure，SOD after the treatment cycle also have significantly different between two groups（P<0. 05 or P<0. 01）. Conclusion There are benign intervention effects of acupuncture on related risk factors in ischemic stroke patients. The acupuncture therapy could be one of the secondary prevention methods to ischemic stroke.