Objective To observe influence of Shuxuetong injection on serum Tumor necrosis factor（TNF-a）and Interleukin 6（IL-6）in patients with acute cerebral infarction and explore its neurological protective mechanisms and clinical significance. Methods with clinical randomized controlled observation method，56 cases were randomly divided into Shuxuetong injection treatment group and the control group of Erigeron breviscapus，28cases in each group. The period of treatment of two groups was 14 days. On 1d，3d，7d and 14d of reatment，serum TNF-a and IL-6 levels were detected. Results Compared with the control group，serum TNF-a and IL-6 were significantly decreased after treatment of 3d，7d and 14d and there were significant differences（P<0. 05）. Conclusion Shuxuetong injection can decrease TNF-a and IL-6 level of treatment group patients to improve neural function defect of acute cerebral infarction patients.