Objective To observe the clinical effect of integrated traditional chinese and western medicine in treatment of patients with diabetic peripheral neuropathy（DPN）. Methods 78 patients with DPN were randomly divided into two groups. All patients were treated with hypoglycemic drugs to control blood sugar within the normal range first. 38 patients were allocated into control group treated with mecobalamin，while 40 patients were allocated into treatment group treated with Prescription for nourishing Qi and activating Blood combined with mecobalamin. Fifteen days is a course of treatment，and both groups were treated for two courses of treatment. In the treatment process，the motor nerve conduction velocity（MNCV）and sensory nerve conduction velocity（SNCV）of median and common peroneal nerve have been observed. Results After two courses of treatment，the total effective rate of treatment group is 90. 00%，and the total effective rate of control group is 71. 05%. By chi-square（χ2）test，there is significant difference in total effective rate compared the control group with the treatment group（P<0. 05），and compared with control group，treatment group has batter clinical effect. The MNCV and SNCV of median and common peroneal nerve are increasing more significantly in both control group and treatment group after treatment，compared with pre-treatment（P<0. 05），and compared with control group，treatment group has batter clinical effect（P<0. 05）. In the treament of control group and treatment group，serious adverse reactions and significant liver and kidney dysfunction did not appear，compared with pre-treatment（P>0. 05）. Conclusion There is significant clinical effect of integrated traditional chinese and western medicine in treatment of patients with diabetic peripheral neuropathy，and the treatment protocols is more secure which is worthy of clinical popularization and application.