Objective To study the pharmacodynamics of Jiawei ZhaQuYin（JWZQY）interventing non-alcoholic fatty liver. Methods SDF level rats were randomly divided into six groups：blank group，model group，positive control group，low-dose group，middle dose group and high dose group. The blank group was given basic feed，the rest of the group was given a high fat diet model，Since the Modeling day，the blank and model rats fed with an equal volume of saline，the positive control group was given the same volume of compound methionine choline solution（0. 038g/ml）orally. Low，medium and high dose group was given the same volume of a solution containing 1g/ml，2g/ml，4g/ml concentration JWZQY accordingly. After 8 weeks，the conventional oil red O method（modified Lillie）was used to observe the morphological changes of the liver tissue，The automatic biochemical analyzer used to measure the level of serum Alanine transaminase，Aspartate Amino Transferase，Triglyceride，Total Cholesterol，Elisa was used to detect the levels of Free Fatty Acid. Results Through light microscope，we can see that the high-fat diet led to liver cells diffuse enlargement and round in rat the hepatic lobule，the sinusoidal smaller even not visible，the cytoplasm contains a large number of red dye fat droplets of varying sizes，showing steatosis. High-dose and medium-dose JWZQY can significantly reduce hepatic steatosis（P<0. 05）. Compared with the model group，The of level serum ALT，AST，TC，TG of the positive control rat was reduced，the difference was statistically significant（P<0. 01），difference of serum ALT，AST，TC，TG level in low-dose group not statistically significant（P>0. 05），Low，medium and high dose group，the serum ALT，AST，TC，TG level was significantly lower，The difference was statistically significant（P<0. 01）. Compared with the positive control group，serum ALT，AST，TC，TG level is reduced in high dose group，the difference was statistically significant（P<0. 01），but in the medium dose group and high dose group，serum ALT，AST，TC，TG no statistically significant difference（P>0. 05）. Compared with model group，the difference of serum FFA in medium dose group was statistically significant（P<0. 01），low-dose serum FFA was no significant difference （P>0. 05）. Conclusion JWZQY can effectively intervene in the experimental non-alcoholic fatty liver，reduce FFA generation，having good market prospects.