Objective To study involving the bone mixture with sodium hyaluronate injection treatment on senile knee osteoarthritis clinical effect and significance. Methods During an April 2013 in September 2008， our hospital diagnosis and treatment of 112 cases of elderly patients with knee osteoarthritis， which were randomly divided into treatment group（articular cavity injection of sodium hyaluronate cooperate internal treatment） and control group（articular cavity injection of sodium hyaluronate）， the 56 cases in each group. Giving patients the above 4 weeks treatment， carries on four to 12 months of follow-up. Results Treatment group total effective rate（87.5%） is significantly higher than the control group total effective rate（69.6%）， P<0.05， with statistical significance. Conclusion Involving the bone mixture with sodium hyaluronate injection treatment of senile knee osteoarthritis clinical effect is good.