Objective Study on Shuyuwan on allergic rhinitis（AR） rat model of curative effect and the impact on the content of serum IgE and IL-4. Methods 60 rats were randomly divided into Normal control group， Model groups， Xin-Qin control group，Shuyuwan in high， medium and low-dose groups（3. 2，1. 6，0. 8g/kg）， 10 in each group. In addition to the normal control group，on five groups of rats were ovalbumin（OVA） sensitization and challenge for modeling. After modeling success，The party Shuyuwan for high， medium and low dose group were used respectively to condense water decoction lavage， Xin-Qin control group given particle gavage. After 14d treatment using enzyme-linked immunosorbent assay（ELISA method） detection of serum IgE and IL-4 levels in rats of each group. Results Modeled after the set of behavioral scores in rats were significantly higher than the control group（P<0. 01）. After treatment the Group behavioral scoring and serum IgE， IL-4 content model group had lower（P<0. 05）. Compare with Xin-Qin control group， Medium-dose group significantly lower serum IgE， IL-4 levels， the difference was statistically significant（P<0. 05）. Conclusion The Shuyuwan can decrease the serum IgE and IL-4 levels in experimental rats， played against allergies and relieve symptoms of allergic rhinitis.