Objective To investigate whether TFH improve the atherosclerosis rats vascular function and its mechanism. Methods 50 male SD rats were divided into 5 groups：blank control group， atherosclerosis group， TFH low， medium and high dose group， After feeding for 60 days. Taking aorta to detect vascular injury condition； Separation and determination of SOD， MDA and ROS content. Elisa technique to detect NADPH oxidase subunit protein Nox4 and ox-LDL expression level. Results Compared AS group to CON， MDA and ROS activity were significantly increased， SOD content decreased significantly； TFH intervention can improve the above indicators； TFH reduce NADPH oxidase protein Nox4 and ox-LDL protein expression level. Conclusion TFH has protective effect of vascular in atherosclerosis rats， Its mechanism could be by lowering Nox4 and ox-LDL protein levels， and reduce ROS generation.