Objective To observe the therapeutic of xiaoluowan combined longxuejie capsules on thyroid nodule patients. Methods 80 patients with thyroid nodules were randomly divided into treatment group（to be treated with xiaoluowan combined longxuejie capsules） and control group（to be treated with euthyrox） with 40 cases in each， three months for a treatment course. Both groups were asked low iodine diet. Observe and analyze comparatively the related indicators（include the maximum diameter measured by ultra-sound and the thyroid function）. Results The total effective rate of treatment was 89. 19% and 45.71% in the treatment group and control group. The maximum diameter of thyroid nodule was significantly decreased after treatment in both groups， especially in the treatment group（P<0.05）. There was no significant difference in thyroid function（P>0.05）. Conclusion The Treatment of xiaoluowan combined longxuejie capsules which was a safe and effective treatment can obviously relieve the symptoms， reduce the maximum diameter of thyroid nodule. 75. A. A