Objective By observation and analysis of the effects of manipulating needles in Baihui， Fengfu， Shenmen and Taichong points on the behaviors， neurological deficits and weights of the rat models with post-stroke depression， to provide scientific evidence for acupuncture of post-stroke depression. Methods Establishing of MCAO models and CUMS models in minds of rats， observing the weights of rats and the changed results of the open field tests and sucrose consumption tests. Results After the treatments， comparing to the results of rats in model group， the weights and the behavioural assessments of rats in acupuncture group and medical group increase markedly（P＜0. 05）；while the behavioural assessments of rats between acupuncture group and medical group are still same（P＞0. 05）. Conclusion Acupuncture of Baihui， Fengfu， Shenmen and Taichong points and Fluoxetine Hydrochloride are both have clinical efficacies， and the efficacies are equivalent.