Objective To observe the effects of Qiangxin decoction on protein expression of regulation cell growth and proliferation in Rats with Adriamycin（ADR）-induced cardiac hypertrophy， and to investigate potential molecular mechanisms of cardiac hypertrophy. Methods Forty Sprague Dawley rats were randomly divided as follows：ADR group， normal control group， rapamycin treatment group， high and low dosage Qiangxin decoction groups. The morphology， hemodynamic， brain natriuretic peptide， and relative protein expression of cardiac hypertrophy were observed. Results Compared with ADR group， Qiangxin decoction treatment significantly inhibited the extent of the cardiac hypertrophy， improved cardiac function， while the expression level of phosphorylated mTOR（p-mTOR）and phosphorylated p70S6K（p- p70S6K）significantly reduced. Conclusion The present study demonstrated that Qiangxin decoction significantly relieve the myocardial hypertrophy and improve the cardiac function， The protective effect of the derivatives could be due to the inhibition of the activities of p-mTOR and p-p70S6K.