Objective To evaluate the effect of Transmetil（S-adenosylmethionine needle）for treatment of intrahepatic cholestasis of pregnancy（ICP）combined with Chinese traditional medicine Yinchen cholagogue Decoction. Methods We retrospectively collected 69 ICP patientsin in our hospital， 35 cases in the treatment group， treated by transmetil combined with traditional Chinese medicine Yinchen cholagogueDecoction， the control group of 34 cases treated by transmetil without Chinese traditional medicine， compared two groups before and after treatment in patients with symptoms， serum bile acid（TBA）， alanine aminotransferase（ALT）and aspartate aminotransferase（AST）levels and observe the pregnancy outcomes， carry on the statistical analysis of the results. Results After treatment， 2 groups of TBA， ALT， AST were decreased than that before treatment（P<0. 05）. After treatment， TBA， ALT， AST decreased more obviously（P<0. 05）than the control group after treatment， the fetal distress， amniotic fluid contamination， neonatal asphyxia， the rate of cesarean section in the treatment group was lower than that in control group（P<0. 05）. Conclusion Transmetil combined with traditional Chinese medicine Yinchen cholagogue Decoction in the treatment of ICP has a more obvious effect than pure Transmetil.