Objective To observe the clinical effect of integration of TCM and west medicine in the treat-ment of globus hytericus. Methods 78 cases of globus hytericus according to the Rome III criteria were randomly divided into the trentment group and the contrast group. The treatment group was treated by TCM（Jiaweidanzhixi-aoyao powder） and west medicine（flupentixol and melitracen）. The contrast group was treated by westen medicine only（flupentixol and melitracen）. Results The total effective ratio of treatiment group and the contrast group was 94.9% and 82.1% respectively（P<0.05）. The treatment group was better than the contrast group in improving both the prime and associated symptoms of golbus hytericus. Conclusion Integration of TCM and west medicine has better effect in treating globus hytericus than westen medicine only.