Objective To study the effects of Linggui Zhugan Decoction（LGZGD）interference on ventricular remodeling（VR）in rats after acute myocardial infarction（AMI）， through observing hemodynamics and the expression of BNP in Serum. Methods The AMI model was induced by ligation of coronary artery. 2 weeks after the modeling， the rats were randomly classified into Sham group， model， captopril， and low， middle and high dosage of LGZGD group. Sham group and the other five groups were ig administered once daily for consecutive 4 weeks. Then the hemodynamic parameters were observed and the levels of BNP in serum were detected by ELISA. Results The low， middle and high dose of Linggui Zhugan Decoction all significantly increased left ventricular systolic pressure（LVSP）， maximal rate of left ventricularpressure of development（+dp/dtmax）and maximal rate of left ventricular pressure of decline（-dp/dtmax）（P<0.05， or P<0.01）， and decreased left ventricular end diastolic pressure（LVEDP）， and the levels of BNP were significantly decreased（P<0.05， or P<0.01）. Conclusion Linggui Zhugan Decoction has marked effects on improving the systolic and diastolic functions of the heart in rats with VR of post-AMI；which might be related to the inhibition of BNP.