Objective To Explore the influence of Fanggan decoction on TNF alpha and IL-6 in the mice infected by influenza a virus（H1N1）， to learn more about Fanggan decoction curative effect mechanism. Methods Choose clean level 96 male ICR mice， were randomly divided into 4 groups：normal control group， model control group， Chinese medicine in Chinese medicine dosage group and positive control group. Sense of Chinese traditional medicine group to prevent decoction medium dose to fill the stomach， positive control group to tamiflu lavage， normal control group and model control group with saline lavage. In for 3 days with the flu virus droplets nasal H1N1 virus infection of animal model is set up. In building 1， 5， 9， 13 days after the random death 6 mice in each group， the serum and lung tissue collection， TNF alpha and IL-6， such as secretion and function. Results 1， Fanggan decoction group is better than the model group in general condition of mice. 2， Fanggan Decoction group had lower H1N1 virus content in lung tissue of mice than those in the model group（P<0. 05）. 3， drug intervention group mice blood serum tumor necrosis factor（TNF alpha）， IL -6， level significantly decreased， compared with the model group had significant difference（P<0. 01）. Conclusion Fanggan decoction can depress the replication of the H1NI virus， depress expression of cytokines TNF-α， IL-6， thereby reducing the excessive release of inflammatory mediators by immune pathological injury caused by inflammation， thus Fanggan decoction can regulate the immune function and improve symptoms.