Objective To establish a method for the determination of five residual solvents in scutellarin. Methods Head-space gas chromatography was established， the chromatographic column was DB-1301（30m×0.32mm×1.0μm）， the carrier gas was N2， the detector was FID， temperature was controlled by program and the solvent was N， N-Dimethylacetamide（DMA）. Results Five residual solvents were completely separated. A good linearity（r=0.9939~0.9999）was obtained. The detection limits of methanol， ethanol， acetone， dichloromethane and DMF were 0.875， 1.338， 1.132， 1.528， 10.56μg·mL-1 respectively；the RSDs of precision were less than 2%； the average recovery rates of the preparation were in the range of 99.15%~103.32%. Conclusion The method is simple， sensitive， accurate and can be used for the quality control of scutellarin.