Objective To discuss the medication rule of Dryness Syndrome treatment in central Yunnan province. Methods To explore section medication rule of Dryness Syndrome treatment in central Yunnan province by collecting 432 relevant medical records which included 396 prescriptions before inputting the ingredients to Excel table and conducting cluster analysis and frequency analysis through SPSS19.0（Statistics Package for the Social Sciences）. Results Chinese medicine used in Dryness Syndrome treatment in central Yunnan province normally has the functions of regulating and reinforcing Qi and Yin（regulating liver Qi， replenishing lung and spleen Qi， supplementing liver and kidney Yin)， and is cold in nature， sweet， bitter or pungent in flour， and acts on the lung and liver meridians. Commonly applied prescriptions are erzhi pill， liuwei dihuang pill； qingzao jiufei decoction； yangyin qingfei decoction. The usage of medicine， which is characterized by definite local features ， reflects the TCM theory of “treating patients according to the three factors of locality， time and the patients themselves. ” and can be applied in clinical practice.