Objective To preliminarily establish KOA differentiation factors integral table and assess it’s reliability. Methods Referring to “A Practical Guide to The Clinical Pathway of Chinese Medicine”，“Diagnostics of Chinese Medicine ”， “Clinical Research Guiding Principle of TCM New Drug” and the characteristics of KOA， we formulated the TCM diagnostic criteria and differentiation factors integral tbale of KOA. Using the Cronbach’s coefficient to test the internal consistency reliability of each dimension in the table. Results Cronbach’s alpha coefficients were Between 0.531 to 0.846,the score of "white and dry fur"was 0.813～0.846. Cronbach’s alpha coefficients of 4 syndrome dimensions were greater than 0.700. Conclusion KOA differentiation factors integral table has good validity. Some items need to be further modified and debugged.